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Estimation of tissue-to-plasma partition coefficients used in physiological pharmacokinetic models

โœ Scribed by Hsiao -Sheng George Chen; Joseph F. Gross

Book ID
112472401
Publisher
Springer
Year
1979
Tongue
English
Weight
446 KB
Volume
7
Category
Article
ISSN
1573-8744

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The tissue:plasma (P t:p ) partition coefficients (PCs) are important drugspecific input parameters in physiologically based pharmacokinetic (PBPK) models used to estimate the disposition of drugs in biota. Until now the use of PBPK models in early stages of the drug discovery process was not possib