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In vitroandin vivoevaluation of the tissue-to-blood partition coefficient for physiological pharmacokinetic models

✍ Scribed by Jiunn Huei Lin; Yuichi Sugiyama; Shoji Awazu; Manabu Hanano


Book ID
112473654
Publisher
Springer
Year
1982
Tongue
English
Weight
542 KB
Volume
10
Category
Article
ISSN
1573-8744

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The tissue:plasma (P t:p ) partition coefficients (PCs) are important drugspecific input parameters in physiologically based pharmacokinetic (PBPK) models used to estimate the disposition of drugs in biota. Until now the use of PBPK models in early stages of the drug discovery process was not possib