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Use of Human CD4 Transgenic Mice for Studying Immunogenicity of HIV-1 Envelope Protein gp120

✍ Scribed by J. Seagal; E. Spectorman; J.M. Gershoni; G.F. Denisova

Book ID
110270672
Publisher
Springer Netherlands
Year
2001
Tongue
English
Weight
105 KB
Volume
10
Category
Article
ISSN
0962-8819

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The mechanisms accounting for T cell depletion in AIDS patients are not yet fully understood, nor are the roles of host factors in HIV pathogenesis. We show here that an ongoing humoral immune response to HIV gp120 can sensitize non-infected cells towards apoptosis. Thus, i.v. injection of 1 ? g rec