Deletion of T lymphocytes in human CD4 transgenic mice induced by HIV-gp120 and gp120-specific antibodies from AIDS patients

An ongoing immune response to HIV envelo

An ongoing immune response to HIV envelope gp120 in human CD4-transgenic mice contributes to T cell decline upon intravenous administration of gp120

✍ Yubin Kang; E. F. Marco Melo; David W. Scott 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 185 KB 👁 2 views

The mechanisms accounting for T cell depletion in AIDS patients are not yet fully understood, nor are the roles of host factors in HIV pathogenesis. We show here that an ongoing humoral immune response to HIV gp120 can sensitize non-infected cells towards apoptosis. Thus, i.v. injection of 1 ? g rec