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Use of cell bleed in a high cell density perfusion culture and multivariable control of biomass and metabolite concentrations

✍ Scribed by J-S. Deschênes; A. Desbiens; M. Perrier; A. Kamen


Book ID
112001530
Publisher
Wiley (John Wiley & Sons)
Year
2006
Tongue
English
Weight
292 KB
Volume
1
Category
Article
ISSN
1932-2135

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Controlled feeding of nutrient supplements to a cell culture to enhance monoclonal antibody productivity has been practiced widely in high-yield, fed-batch processes. In this study, a similar feeding concept has been applied to a perfused culture and evaluated for the effects on bioreactor productiv