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Acoustic Cell Filter for High Density Perfusion Culture of Hybridoma Cells

✍ Scribed by Trampler, Felix; Sonderhoff, Stefan A.; Pui, Phylis W. S.; Kilburn, Douglas G.; Piret, James M.


Book ID
109902361
Publisher
Springer Science and Business Media LLC
Year
1994
Tongue
English
Weight
649 KB
Volume
12
Category
Article
ISSN
0733-222X

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## Abstract **BACKGROUND:** The production of Monoclonal antibodies (mAbs) is often performed in batch or fed‐batch operations where low cell densities and low volumetric productivities are achieved. The main bottleneck of both processes is the short operating time with productive cells at maximum