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Ursodeoxycholic acid prevents taurolithocholate induced cholestasis in rat liver


Book ID
122756876
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
56 KB
Volume
7
Category
Article
ISSN
0168-8278

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NorUDCA (24-norursodeoxycholic acid), the C₂₃-homolog of ursodeoxycholic acid (UDCA), showed remarkable therapeutic effects in cholestatic Mdr2 (Abcb4) (multidrug resistance protein 2/ATP-binding cassette b4) knockout mice with sclerosing/fibrosing cholangitis. In contrast to UDCA, norUDCA is ineffi