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[311] URSODEOXYCHOLIC ACID, BUT NOT NORURSODEOXYCHOLIC ACID REVERSES TAUROLITHOCHOLIC ACID-INDUCED CHOLESTASIS IN RAT LIVER

✍ Scribed by S. Maitz; G.U. Denk; R. Wimmer; P. Invernizzi; A.F. Hofmann; U. Beuers


Book ID
117375409
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
289 KB
Volume
46
Category
Article
ISSN
0168-8278

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NorUDCA (24-norursodeoxycholic acid), the C₂₃-homolog of ursodeoxycholic acid (UDCA), showed remarkable therapeutic effects in cholestatic Mdr2 (Abcb4) (multidrug resistance protein 2/ATP-binding cassette b4) knockout mice with sclerosing/fibrosing cholangitis. In contrast to UDCA, norUDCA is ineffi