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Partial protection by taurocholic and ursodeoxycholic acids of cyclosporin A-induced cholestasis in isolated perfused rat liver

✍ Scribed by M. El-Naggere; G. Bouchard; B. Tuchweber; I.M. Yousef

Book ID: 118881553
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 132 KB
Volume: 108
Category: Article
ISSN: 0016-5085
DOI: 10.1016/0016-5085(95)28548-2

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Methotrexate (MTX) and cyclosporine (CyA) are coadministered in a number of diseases. In this study, the effects of CyA on the hepatobiliary disposition of MTX were investigated in an isolated perfused rat liver model. A bolus 5-mg dose of MTX was added to a recirculating perfusate in the absence or