Methotrexate (MTX) and cyclosporine (CyA) are coadministered in a number of diseases. In this study, the effects of CyA on the hepatobiliary disposition of MTX were investigated in an isolated perfused rat liver model. A bolus 5-mg dose of MTX was added to a recirculating perfusate in the absence or
Effect of Pharmacological Modulation of Liver P-Glycoproteins on Cyclosporin A Biliary Excretion and Cholestasis A Study in Isolated Perfused Rat Liver
β Scribed by Marco Delle Monache; Alessandro Gigliozzi; Antonio Benedetti; Luca Marucci; Adriano Bini; Chiara Francia; Emanuela Papa; Emanuele Di Cosimo; Flavia Fraioli; Anne Marie Jezequel; Domenico Alvaro
- Book ID
- 111567357
- Publisher
- Springer US
- Year
- 1999
- Tongue
- English
- Weight
- 206 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0163-2116
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