Urokinase-type plasminogen activator, its receptor and inhibitor expression in hepatocellular carcinoma relation to cancer invasiveness and prognosis
β Scribed by Qi Zheng; Zhaoyou Tang; Zhiquan Wu; Daren Shi; Huibin Tang; Yunsong Zhu; Houyan Song
- Publisher
- Chinese Anti-Cancer Association
- Year
- 1998
- Tongue
- English
- Weight
- 236 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1000-9604
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π SIMILAR VOLUMES
The urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in tumour invasion. Previous studies have shown by RT-PCR that uPA and uPAR mRNAs are expressed in human hepatocellular carcinoma (HCC). Here, in situ hybridization, immunohistochemistry, and double immunoΒ―
involved in tumor invasion and metastasis.
The expression of urokinase-type plasminogen activator (u-PA), its receptor (u-PAR) and metalloproteases activity were analyzed in 4 human gastric-cancer cell lines (AGS, Hs746T, SNU-1, and SNU-5), in an attempt to relate these activities to their invasive potential and tumorigenicity on the modifie
## Abstract The involvement of the urokinaseβtype plasminogen activator (uPA) system in particular has been extensively studied in the pathogenesis of cancer. The molecular role of the uPA receptor (uPAR) is well characterized with its participation in cell migration and extracellular matrix (ECM)