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Expression and cellular localization of the urokinase-type plasminogen activator and its receptor in human hepatocellular carcinoma

โœ Scribed by Dubuisson, L.; Monvoisin, A.; Nielsen, B. S.; Le Bail, B.; Bioulac-Sage, P.; Rosenbaum, J.

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
437 KB
Volume
190
Category
Article
ISSN
0022-3417

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โœฆ Synopsis

The urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in tumour invasion. Previous studies have shown by RT-PCR that uPA and uPAR mRNAs are expressed in human hepatocellular carcinoma (HCC). Here, in situ hybridization, immunohistochemistry, and double immunoยฏuorescence were used to identify the cells expressing uPA and uPAR in 26 HCCs. The results indicate that uPA and uPAR were expressed in every case, almost exclusively in stromal cells, mostly myoยฎbroblasts and macrophages, except for rare tumoural hepatocytes expressing cytokeratin 7. These results show the important role of stromal cells of HCC in the pericellular proteolysis which facilitates cancer cell invasion.

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