Invasion and metastasis of hepatocellular carcinoma in relation to urokinase-type plasminogen activator, its receptor and inhibitor
β Scribed by Q. Zheng; Z.-Y. Tang; Q. Xue; D.-R. Shi; H.-Y. Song; H.-B. Tang
- Publisher
- Springer-Verlag
- Year
- 2000
- Tongue
- English
- Weight
- 152 KB
- Volume
- 126
- Category
- Article
- ISSN
- 1432-1335
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involved in tumor invasion and metastasis.
The urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in tumour invasion. Previous studies have shown by RT-PCR that uPA and uPAR mRNAs are expressed in human hepatocellular carcinoma (HCC). Here, in situ hybridization, immunohistochemistry, and double immunoΒ―
## BACKGROUND. Urokinase plasminogen activator (u-PA) plays a key role in the metastatic process by promoting plasmin mediated tissue degradation. Metastatic cell invasion requires localized proteolysis, which may be directed by u-PA receptor. The binding of u-PA and PAI-1 to the u-PA-receptor may
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v