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Ureterosigmoidostomy in rats: A model for the study of bladder tumour carcinogenesis and cocarcinogenesis

✍ Scribed by Rowland, Randall G. ;Grayhack, John T. ;Oyasu, Ryoichi

Publisher: Springer
Year: 1979
Tongue: English
Weight: 352 KB
Volume: 7
Category: Article
ISSN: 0300-5623
DOI: 10.1007/bf00262922

No coin nor oath required. For personal study only.

✦ Synopsis

A modified Coffey I ureterosigmoidostomy has been developed in rats as a model of urinary diversion for studying bladder carcinogenesis and co-carcinogenesis. Diverted and sham-operated animals were killed at 1, 3 and 6 months. Excretory urograms revealed minimal hydroureteronephrosis in most diverted animals. Upper tract bacterial colonisation was 9 times more frequent in diverted animals. Approximately one-third of the diverted animals had focal cortical scarring; however, renal function was normal in all groups as assessed by serum creatinine and electrolytes. These studies indicate that ureterosigmoidostomy in rats is a satisfactory model of urinary diversion for studying carcinogenesis.

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