Guinea pig as an animal model for the study of urinary bladder function in the normal and obstructed state

✍ Scribed by Jacek L. Mostwin; Omer M. A. Karim; Gommert Van Koeveringe; Narihito Seki

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 639 KB
• Volume: 13
• Category: Article
• ISSN: 0733-2467
• DOI: 10.1002/nau.1930130206

✦ Synopsis

The guinea pig has become an excellent nicdcl for the study of mechanical and electrical inechanisins regulating bladder function in the normal and obstructed state. Much preliminaq work has been donc on the in vitro behavior of the dctrusor smooth muscle. The tissuc has permitted electrophysiological studies by sucrose gap. microelectrtde, and patch clamp technique. Excellent urodynamic studies can be performed under anesthesia. A recent nicdel o f bladder obstruction has resulted in a source of tissue which is suitable for electrophysiological analysis of [he muscle. Low-cost and simple animal care requirements perniit large-scale studies corrclating urtdynamic, structural. biochemical, contractile. and e1ectrophysir)logical changes in response to obstruction.