Uptake of propranolol by microvessels is
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Atsushi Kurihara; Hiroshi Suzuki; Yasufumi Sawada; Yuichi Sugiyama; Tatsuji Iga;
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Article
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1987
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John Wiley and Sons
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English
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To study the transport system of propranolol (PL), a basic drug, in the blood-brain barrier, the uptake of PL into isolated bovine brain microvessels was investigated. The uptake of PL was a concentrative one via saturable process (Km = 42.5 microM) that was decreased by hypothermia (Q10 = 2.2), but