The effect of protein binding on ivermectin uptake by bovine brain microvessel endothelial cells
β Scribed by K. L. Audus; S. R. Knaub; F. L. Guillot; J. M. Schaeffer
- Publisher
- Springer Netherlands
- Year
- 1992
- Tongue
- English
- Weight
- 826 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0165-7380
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The binding of 'L51-insulin to primary cultures of bovine brain microvessel endothlial cells was examined. Insulin binding was both time and temperature dependent and inhibited by excess unlabeled insulin. Furthermore, the specific binding of insulin was polarized to the apical side of the cell mono
Cultured capillary endothelial cells, derived from bovine brain, and maintained on a plastic substratum synthesized predominantly interstitial collagens of which approximately 75 per cent were secreted into the medium. When grown on a native hydrated collagen type I gel, although no marked alteratio