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Uptake as a Determinant of Methotrexate Response in Mouse Leukemias

✍ Scribed by Kessel, D.; Hall, T. C.; Roberts, D.; Wodjnsky, I.


Book ID
121175121
Publisher
American Association for the Advancement of Science
Year
1965
Tongue
English
Weight
785 KB
Volume
150
Category
Article
ISSN
0036-8075

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Inhibition of methionine uptake by metho
✍ Kevin J. Scanlon; Arlene R. Cashmore; Mohammed Kashani-Sabet; Michele Pallai; Ro πŸ“‚ Article πŸ“… 1987 πŸ› Springer 🌐 English βš– 355 KB

Methionine-auxotrophic L1210 cells were used to study the effect of methotrexate (MTX) on methionine uptake and metabolism. MTX was shown to inhibit amino acid transport systems and cause a decrease of methionine uptake into L1210 cells. Conversely, a nonmetabolizable amino acid analogue reduced MTX