✦ LIBER ✦

Unravelling seemingly complex chemistry of reactions using electrospray ionization mass spectrometry

✍ Scribed by Ray Bakhtiar; Cornelis E. C. A. Hop

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 195 KB
Volume: 12
Category: Article
ISSN: 0894-3230
DOI: 10.1002/(sici)1099-1395(199907)12:7<511::aid-poc160>3.0.co;2-s

No coin nor oath required. For personal study only.

✦ Synopsis

Since its discovery, electrospray ionization mass spectrometry (ESI-MS) has provided valuable information on structurally specific biomolecular interactions, including DNA-drug, enzyme-inhibitor, DNAprotein and protein-protein interactions. In addition, this technique has emerged as a powerful tool in probing the structural modification of large molecules. However, ESI-MS has been underutilized in analysis and mechanistic studies involving small molecules. Here, a brief overview is presented to familiarize non-specialists with ESI-MS applications in analysis and mechanistic studies of small molecules. For more advanced applications (e.g. biopolymers) or detailed analytical descriptions of the ionization processes and the equipment, readers are referred to a number of excellent reviews and books.

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