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Unnaturally configured 13-epi steroids: full 1H and 13C assignments and ring C–D conformations from 1H, 1H vicinal couplings

✍ Scribed by Lee Fielding; Yolande Diepeveen; Dan Fletcher; Niall Hamilton

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
190 KB
Volume
39
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

Six steroids with inverted stereochemistry at C‐13 (13‐epi) were studied. Measurement of vicinal proton–proton couplings was facilitated by a 1D TOCSY experiment, which provided efficient deconvolution of the ring D protons from other signals. A simple semi‐quantitative analysis of the ring D couplings was found to be sufficient to determine the conformation of ring D. Examples of 13α, 14β half‐chair, 17β envelope and 16β envelope conformations were found. Copyright © 2001 John Wiley & Sons, Ltd.

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