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Unique Methylation Signatures and Molecular Subclasses of Barrett's Esophagus and Esophageal Adenocarcinoma Revealed by Methylation Array Analysis

✍ Scribed by Kaz, Andrew ;Wong, Chao-Jen ;Virgin, Jeffrey B. ;Washington, Kay ;Leidner, Rom S. ;Chak, Amitabh ;Grady, William M.

Book ID: 122125851
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 44 KB
Volume: 140
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(11)63387-8

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## Abstract Hypermethylation of secreted frizzled‐related proteins (__SFRP__) genes frequently occurs with several cancers but has not been studied in esophageal adenocarcinoma or its precursor—Barrett's esophagus. To explore the role of __SFRP__ methylation in the neoplastic progression of Barrett