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Similarity of aberrant DNA methylation in Barrett's esophagus and esophageal adenocarcinoma

✍ Scribed by Eric Smith; Neville J De Young; Sandra J Pavey; Nicholas K Hayward; Derek J Nancarrow; David C Whiteman; B Mark Smithers; Andrew R Ruszkiewicz; Andrew D Clouston; David C Gotley; Peter G Devitt; Glyn G Jamieson; Paul A Drew

Book ID
119902001
Publisher
BioMed Central
Year
2008
Tongue
English
Weight
454 KB
Volume
7
Category
Article
ISSN
1476-4598

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## Abstract Hypermethylation of secreted frizzled‐related proteins (__SFRP__) genes frequently occurs with several cancers but has not been studied in esophageal adenocarcinoma or its precursorβ€”Barrett's esophagus. To explore the role of __SFRP__ methylation in the neoplastic progression of Barrett