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Unique binding of a non-natural l,l,l-substrate by isopenicillin N synthase

✍ Scribed by Annaleise R. Howard-Jones; Peter J. Rutledge; Ian J. Clifton; Robert M. Adlington; Jack E. Baldwin


Book ID
116291283
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
304 KB
Volume
336
Category
Article
ISSN
0006-291X

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πŸ“œ SIMILAR VOLUMES


Synthesis of Ξ΄-(l-Ξ±-aminoadipoyl)-l-cyst
✍ SigthΓ³r PΓ©tursson; Jack E Baldwin πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 491 KB

The paper describes the synthesis of two epimeric tdpeptides &(L-cx-aminoadipoyl)-L-cysteinyI-D-(Omethyl)-D-threonine (13) and &(L-ct-aminoadipoyl)-L-cysteinyl-D-(O-methyl)-D-allothreonine ( 14), modified substrates for the isopenicillin-N synthase enzyme. The D-allothreonine tripeptide ( 14) has be