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Structural Studies on the Reaction of Isopenicillin N Synthase with the Truncated Substrate Analogues δ-( l -α-aminoadipoyl)- l -cysteinyl-glycine and δ-( l -α-aminoadipoyl)- l -cysteinyl- d -alanine †,‡

✍ Scribed by Long, Alexandra J.; Clifton, Ian J.; Roach, Peter L.; Baldwin, Jack E.; Rutledge, Peter J.; Schofield, Christopher J.


Book ID
127181052
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
376 KB
Volume
44
Category
Article
ISSN
0006-2960

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Synthesis of δ-(l-α-aminoadipoyl)-l-cyst
✍ Sigthór Pétursson; Jack E Baldwin 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 491 KB

The paper describes the synthesis of two epimeric tdpeptides &(L-cx-aminoadipoyl)-L-cysteinyI-D-(Omethyl)-D-threonine (13) and &(L-ct-aminoadipoyl)-L-cysteinyl-D-(O-methyl)-D-allothreonine ( 14), modified substrates for the isopenicillin-N synthase enzyme. The D-allothreonine tripeptide ( 14) has be