Unexpected Prad-1 amplification in multiple simultaneous localisations of squamous cell carcinoma of the head and neck
β Scribed by Klijanienko, Jerzy; Bianchi, A.; Conti, C.J.; Cvitkovic, E.; Janot, F.; Luboinski, B.
- Book ID
- 123034407
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 116 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0959-8049
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## Background. Abnormalities in chromosome llq13 regions have been frequently found in head and neck squamous carcinoma. Recent studies indicate that the PRAD-1 (also CCNDI), which encodes cyclin D1, is a putative oncogene that is an important component of this region. Methods. DNA was extracted
The presence of gene amplification was determined in 66 fresh head-and-neck SCC specimens using a battery of 9 different probes. Amplification of at least one gene was found in I 2 samples (18%), of which 7 were amplified at multiple loci (58%). We observed amplifications for EGFR (10% of samples) a