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Unchanged rate of axonal regeneration by cyclophosphamide in rat sciatic nerve

โœ Scribed by Komiya, Yoshiaki

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
137 KB
Volume
13
Category
Article
ISSN
0022-3034

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โœฆ Synopsis

Abstract

The rates of axonal regeneration and initial delay in motor and sensory axons of cyclophosphamideโ€treated and control rat sciatic nerves after cold injury were determined by using fast axoplasmic transport. The rates in motor and sensory nerves were not significantly different between the two groups. The difference of initial delay in motor nerve was not significant, but in sensory nerve the drugโ€treated group showed a longer initial delay than the control. These results suggest that the enhancement of motor function recovery by cyclophosphamide is not due directly to an increased rate of axonal regeneration, nor to a decreased initial delay.

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