𝔖 Bobbio Scriptorium
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Unbalanced growth in mouse cells with amplified dhfr genes

✍ Scribed by R. M. Snapka; S. Ge; J. Trask; F. Robertson


Book ID
108677614
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
818 KB
Volume
30
Category
Article
ISSN
0960-7722

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## Abstract Flow cytometry indicated that significant amounts of dsRNA were accumulated in HeLa S3 cells blocked at or near G~1~/S boundary by hydroxyurea (HU) or excess thymidine (TdR). The dsRNA/DNA ratio increased in these cells in a manner characteristic of unbalanced cell growth. In HU‐treated