We examined 22 cases of renal-cell carcinoma (RCC) for structural alterations of the epidermal growth factor receptor (ECFR) gene and found gene amplification in one case of high-stag+high-grade RCC. Dot blot analysis of the total RNA from tumorous and normal kidney tissues revealed overexpression o
โฆ LIBER โฆ
Amplified, overexpressed and rearranged epidermal growth factor receptor gene in a human astrocytoma cell line
โ Scribed by Jorge Filmus; Michael N. Pollak; J.Gregory Cairncross; Ronald N. Buick
- Book ID
- 115759088
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 839 KB
- Volume
- 131
- Category
- Article
- ISSN
- 0006-291X
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The redistribution of 0-adrenergic receptors (6-AR) during agonist-induced desensitization has been compared to the process of receptor-mediated endoc tosis of epidermal growth factor (EGF) in human astrocytoma cells (1321N1). [' 51]EGF exhibited saturable binding to high affinity (K, = 1-2 nM) rece