Growth stimulation and epidermal growth factor receptor induction in cyclooxygenase-overexpressing human colon carcinoma cells
β Scribed by Tanihiro Yoshimoto; Takahiro Kinoshita; Yoshitaka Takahashi; Toshiki Sakashita; Hiroyasu Inoue; Tadashi Tanabe
- Book ID
- 114101077
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 68 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0090-6980
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Human colon cancer cell lines express epidermal growth factor (EGF) mRNA, secrete EGF and may respond to it __via__ the cellβsurface EGF receptor (EGFR). Expression of these molecules in human colon and colon tumor, however, is not clear. Reverse transcriptionβpolymerase chain reaction
We examined 22 cases of renal-cell carcinoma (RCC) for structural alterations of the epidermal growth factor receptor (ECFR) gene and found gene amplification in one case of high-stag+high-grade RCC. Dot blot analysis of the total RNA from tumorous and normal kidney tissues revealed overexpression o