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Ubiquitination-Dependent Proteolysis of O 6 -Methylguanine-DNA Methyltransferase in Human and Murine Tumor Cells following Inactivation with O 6 -Benzylguanine or 1,3-Bis(2-chloroethyl)-1-nitrosourea †

✍ Scribed by Srivenugopal, Kalkunte S.; Yuan, Xiao-Hua; Friedman, Henry S.; Ali-Osman, Francis


Book ID
126439921
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
357 KB
Volume
35
Category
Article
ISSN
0006-2960

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Contribution of O6-methylguanine-DNA met
✍ Michael S. Bobola; Mitchel S. Berger; John R. Silber 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 711 KB

## Abstract To assess the possible role of the DNA repair protein __O__^6^‐methylguanine‐DNA methyltransferase (MGMT) in resistance of brain neoplasms to the clinically important chloroethylating agent 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea (BCNU), we quantitated MGMT activity, BCNU survival, and the