## Abstract Forward mutations induced by 1‐(2‐chloroethyl)‐3‐cyclohexyl‐1‐nitrosourea (a) in the __lacl__ gene of __Escherichia coli__ were recovered from bacteria proficient (Ogt^+^ Ada^+^) and deficient (Ogt^−^ Ada^−^) in __O__^6^‐alkylguanine‐DNA alkyltransferase activity. A CCNU dose of 1 mM wa
Effect of temozolomide and dacarbazine on O6-alkylguanine-DNA alkyltransferase activity and sensitivity of human tumor cells and xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea
✍ Scribed by R. Brian Mitchell; M. Eileen Dolan
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 547 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract To assess the possible role of the DNA repair protein __O__^6^‐methylguanine‐DNA methyltransferase (MGMT) in resistance of brain neoplasms to the clinically important chloroethylating agent 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea (BCNU), we quantitated MGMT activity, BCNU survival, and the
## Abstract The effects of single‐agent therapy with two clinically useful drugs, 5‐fluorouracil (5‐FU) and 1‐3‐bis‐(2‐chloro‐ethyl)‐1‐nitrosourea (BCNU) against nine human colorectal tumors (rectum T 157 and T 348, lung metastasis T 84, lymph‐node metastasis T 245, colon, T 183, T 219, T 347, T 36