U-Pin Polyamide Motif for Recognition of the DNA Minor Groove
✍ Scribed by Alexander Heckel; Peter B. Dervan
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 585 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0947-6539
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📜 SIMILAR VOLUMES
## Abstract Crescent‐shaped polyamides composed of aromatic amino acids, __i.e.__, 1‐methyl‐1__H__‐imidazole **Im**, 1‐methyl‐1__H__‐pyrrole **Py**, and 3‐hydroxy‐1__H__‐pyrrole **Hp**, bind in the minor groove of DNA as 2 : 1 and 1 : 1 ligand/DNA complexes. DNA‐Sequence specificity can be attribut
## Abstract Antiparallel polyamides containing 1__H__‐pyrrole, 1__H__‐imidazole, and 3‐hydroxy‐1__H__‐pyrrole amino acids display a preference for minor‐groove binding oriented NC with respect to the 5′‐3′ direction of the DNA helix. We find that replacement of a central Py/Py pair with a __β__/__