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Influence of β-Alanine on Hairpin Polyamide Orientation in the DNA Minor Groove

✍ Scribed by Victor C. Rucker; Christian Melander; Peter B. Dervan

Publisher
John Wiley and Sons
Year
2003
Tongue
German
Weight
398 KB
Volume
86
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Antiparallel polyamides containing 1__H__‐pyrrole, 1__H__‐imidazole, and 3‐hydroxy‐1__H__‐pyrrole amino acids display a preference for minor‐groove binding oriented NC with respect to the 5′‐3′ direction of the DNA helix. We find that replacement of a central Py/Py pair with a β/β pair within a ten‐ring hairpin relaxes the orientation preference and, for some DNA sequences, causes the polyamide to prefer the opposite CN orientation. Substitution of the achiral γ‐aminobutanoic acid (γ) with either (R)(or S)‐2‐(acetylamino)‐4‐aminobutanoic acid moderates the orientation preference of the 2‐β‐2‐hairpin.

📜 SIMILAR VOLUMES

Dependence of the hydration shell struct
Dependence of the hydration shell structure in the minor groove of the DNA double helix on the groove width as revealed by monte carlo simulation
✍ A. V. Teplukhin; V. I. Poltev; V. P. Chuprina 📂 Article 📅 1991 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 669 KB

## Abstract The hydration shell of several conformations of the polynucleotides poly(dA) · poly(dT), poly (dA) · poly (dU), and poly (dA‐dl) · poly (dT‐dC) has been simulated using the Monte Carlo method (Metropolis sampling). Calculations have shown that the structure of the hydration shell of the