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Discrimination of A/T Sequences in the Minor Groove of DNA within a Cyclic Polyamide Motif

✍ Scribed by Christian Melander; David M. Herman; Peter B. Dervan


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
318 KB
Volume
6
Category
Article
ISSN
0947-6539

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✍ FE Kleiman; A. Oller Ramírez; B Akerman; R Dodelson de Kremer; RA Gravel; CE Arg 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 363 KB 👁 1 views

While screening for new mutations in the HEXB gene, which encodes the beta-subunit of beta-hexosaminidase, a TG deletion (deltaTG) was found in the 3' untranslated region (3'UTR) of the gene, 7 bp upstream from the polyadenylation signal. Examination of DNA samples of 145 unrelated Argentinean indiv