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TWO MUTATIONS IDENTIFIED IN THE ANDROGEN RECEPTOR OF THE NEW HUMAN PROSTATE CANCER CELL LINE MDA PCA 2A

✍ Scribed by ZHAO, XIAO-YAN; BOYLE, BRYAN; KRISHNAN, ARUNA V.; NAVONE, NORA M.; PEEHL, DONNA M.; FELDMAN, DAVID

Book ID: 121901508
Publisher: Lippincott Williams and Wilkins
Year: 1999
Tongue: English
Weight: 304 KB
Volume: 162
Category: Article
ISSN: 0022-5347
DOI: 10.1016/S0022-5347(05)68158-X

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## Abstract Androgen receptor (AR) mutations that modify both the ligand binding and the transactivation capacities of the AR represent one of the mechanisms involved in the transition of prostate cancer (PCa) from androgen‐dependent to androgen‐independent growth. We use a yeast‐based functional a