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Two Methods for Direct ortho -Arylation of Benzoic Acids

✍ Scribed by Chiong, Hendrich A.; Pham, Quynh-Nhu; Daugulis, Olafs


Book ID
120068855
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
155 KB
Volume
129
Category
Article
ISSN
0002-7863

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## Abstract Direct synthesis of γ‐substituted phthalids from related __ortho__‐aryl benzoic acids with 48–85% yield are covered. The direct oxidation in the presence of peroxydisulphate‐copper (II) chloride in aqueous medium was applied. The reaction is highly regioselective and leads exclusively t