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Two Methods for Direct ortho-Arylation of Benzoic Acids.

✍ Scribed by Hendrich A. Chiong; Quynh-Nhu Pham; Olafs Daugulis


Book ID
102012560
Publisher
John Wiley and Sons
Year
2007
Weight
42 KB
Volume
38
Category
Article
ISSN
0931-7597

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Direct synthesis of Ξ³-substituted phthal
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## Abstract Direct synthesis of γ‐substituted phthalids from related __ortho__‐aryl benzoic acids with 48–85% yield are covered. The direct oxidation in the presence of peroxydisulphate‐copper (II) chloride in aqueous medium was applied. The reaction is highly regioselective and leads exclusively t