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Two Crystal Forms of the Extracellular Domain of Type I Tumor Necrosis Factor Receptor

✍ Scribed by Lynn E. Rodseth; Barbara Brandhuber; Tracey Q. Devine; Michael J. Eck; Karin Hale; James H. Naismith; Stephen R. Sprang


Book ID
115626664
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
225 KB
Volume
239
Category
Article
ISSN
0022-2836

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We evaluated the effect of UV-B light at 302 nm on a model therapeutic protein, 2.6 D type I soluble tumor necrosis factor receptor (sTNF-RI). This protein contains a single Trp at position 97 and seven native disulfide bonds along its interior from the N to the C-terminus. At a protein concentratio