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Tumorigenicity of the Optical Enantiomers of the Diastereomeric Benzo[a]pyrene 7,8-diol-9,10-epoxides in Newborn Mice: Exceptional Activity of (+)-7β ,8α -dihydroxy-9α ,10α -epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

✍ Scribed by M. K. Buening, P. G. Wislocki, W. Levin, H. Yagi, D. R. Thakker, H. Akagi, M. Koreeda, D. M. Jerina and A. H. Conney


Book ID
123655330
Publisher
National Academy of Sciences
Year
1978
Tongue
English
Weight
645 KB
Volume
75
Category
Article
ISSN
0027-8424

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✍ M. R. Osborne; P. Brookes; F. A. Beland; R. G. Harvey 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 539 KB

## Abstract The reaction of (±)‐7α,8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo(__a__)pyrene (BP diol epoxide) with DNA, followed by enzymatic hydrolysis and LH 20 Sephadex column chromatography, yielded products containing a purine deoxyribonucleoside linked to a 7,8,9,10‐tetrahydrobenzo(__a