Tumor suppressor p53 regulates heparanase gene expression
β Scribed by Baraz, L; Haupt, Y; Elkin, M; Peretz, T; Vlodavsky, I
- Book ID
- 110070446
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 216 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The p53 tumor suppressor protein is a key transcription factor that regulates several signaling pathways involved in the cell's response to stress. Through stressβinduced activation, p53 accumulates and triggers the expression of target genes that protect the genetic integrity of all ce
Transgenic mice deficient for the p53 gene were reported to frequently develop angiosarcoma (AS), suggesting that alterations in the gene are associated with tumorigenesis of AS. However, little is known about genetic changes, including p53 gene alterations, in human AS because of its rarity. We ana