Tumor Suppressor Genes: Prospects for Cancer Therapies
β Scribed by Bertelsen, Arthur H. ;Beaudry, Gary A. ;Stoller, Timothy J. ;Trotta, Paul P. ;Sherman, Michael I.
- Book ID
- 109901810
- Publisher
- Nature Publishing Group
- Year
- 1995
- Tongue
- English
- Weight
- 550 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1087-0156
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The genetic determinants for most breast cancer cases remain elusive. However, a mutation in a tumor suppressor gene, such as p53, BRCA1, BRCA2, or ATM, has been determined to be one mechanism of breast carcinogenesis. It has been established that inherited mutations in p53, BRCA1, and BRCA2 signifi
## Abstract Loss of heterozygosity on the long arm of chromosome 16 is one of the most frequent genetic events in breast cancer, suggesting the presence of one or more classic tumorβsuppressor genes (TSGs). It has been shown that Eβcadherin is the TSG on 16q in lobular tumors. In a search for the t