Tumor-Suppressor genes in pancreatic cancer
β Scribed by Hruban, Ralph H. ;Offerhaus, G. Johan A. ;Kern, Scott E. ;Goggins, Michael ;Wilentz, Robb E. ;Yeo, Charles J.
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 217 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0944-1166
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The genetic determinants for most breast cancer cases remain elusive. However, a mutation in a tumor suppressor gene, such as p53, BRCA1, BRCA2, or ATM, has been determined to be one mechanism of breast carcinogenesis. It has been established that inherited mutations in p53, BRCA1, and BRCA2 signifi
## Abstract Loss of heterozygosity on the long arm of chromosome 16 is one of the most frequent genetic events in breast cancer, suggesting the presence of one or more classic tumorβsuppressor genes (TSGs). It has been shown that Eβcadherin is the TSG on 16q in lobular tumors. In a search for the t
## Abstract The retinoblastoma sensitivity protein (Rb) and the p53 gene product both appear to function as negative regulators of cell division or abnormal cellular growth in some differentiated cell types. Several types of cancers have been shown to be derived from cells that have extensively mut