Taxoids bearing methyldisulfanyl(alkanoyl) groups for taxoid-antibody immunoconjugates were designed, synthesized and their activities evaluated. A highly cytotoxic C-10 methyldisulfanylpropanoyl taxoid was conjugated to monoclonal antibodies recognizing the epidermal growth factor receptor (EGFR) e
✦ LIBER ✦
Tumor-Specific Novel Taxoid−Monoclonal Antibody Conjugates
✍ Scribed by Ojima, Iwao; Geng, Xudong; Wu, Xinyuan; Qu, Chuanxing; Borella, Christopher P.; Xie, Hongsheng; Wilhelm, Sharon D.; Leece, Barbara A.; Bartle, Laura M.; Goldmacher, Victor S.; Chari, Ravi V. J.
- Book ID
- 120622157
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 95 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0022-2623
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