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Novel Peptide Conjugates for Tumor-Specific Chemotherapy§

✍ Scribed by Rothen-Rutishauser, Barbara; Wunderli-Allenspach, Heidi; Beck-Sickinger, Annette G.; Langer, Michael; Kratz, Felix

Book ID
111938494
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
463 KB
Volume
44
Category
Article
ISSN
0022-2623

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Taxoids bearing methyldisulfanyl(alkanoyl) groups for taxoid-antibody immunoconjugates were designed, synthesized and their activities evaluated. A highly cytotoxic C-10 methyldisulfanylpropanoyl taxoid was conjugated to monoclonal antibodies recognizing the epidermal growth factor receptor (EGFR) e