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4828991 Tumor specific monoclonal antibodies

โœ Scribed by Al-Mujaini, Abdullah; Ganesh, Anuradha; William, Ranjan; Al Azri, Faisal

Book ID
122067307
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
72 KB
Volume
7
Category
Article
ISSN
0734-9750

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Taxoids bearing methyldisulfanyl(alkanoyl) groups for taxoid-antibody immunoconjugates were designed, synthesized and their activities evaluated. A highly cytotoxic C-10 methyldisulfanylpropanoyl taxoid was conjugated to monoclonal antibodies recognizing the epidermal growth factor receptor (EGFR) e