Thrombospondin (TSP-1) is a large glycoprotein secreted by platelets and synthesized by many cell types, including endothelial and tumor cells. Although controversy exists about the biological function of TSP-1, the following observations suggest that TSP-1 may potentiate tumor progression. (1) Tumo
β¦ LIBER β¦
Tumor progression: the effects of thrombospondin-1 and -2
β Scribed by Jack Lawler; Michael Detmar
- Book ID
- 116306714
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 146 KB
- Volume
- 36
- Category
- Article
- ISSN
- 1357-2725
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The antiangiogenic extracellular matrix protein thrombospondin-1 (TSP-1) inhibits tumor growth and metastasis in animals. However, the clinical relevance of such findings are equivocal as increased stromal TSP-1 expression has been associated with either good or poor prognosis. In an effort to obtai