✦ LIBER ✦

The role of thrombospondin-1 in tumor progression and angiogenesis

✍ Scribed by George P. Tuszynski; Roberto F. Nicosia

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 834 KB
Volume: 18
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950180113

No coin nor oath required. For personal study only.

✦ Synopsis

Thrombospondin (TSP-1) is a large glycoprotein secreted by platelets and synthesized by many cell types, including endothelial and tumor cells. Although controversy exists about the biological function of TSP-1, the following observations suggest that TSP-1 may potentiate tumor progression. (1) Tumor metastases in mice are promoted by TSP-1 and inhibited by anti-TSP-1 antibodies. (2) TSP-1 promotes tumor cell adhesion, migration and invasion. (3) TSP-1 promotes angiogenesis in the rat aorta model. (4) TSP-1 up-regulates the plasminogen activator system through a mechanism involving the activation of TGF-P1. ( 5) Human tumors express increased levels of the CSVTCG-specific TSP-1 receptor. ( 6) Tumor stroma is enriched in TSP-1. ( 7) Cancer patients have high blood levels of TSP-1. ( 8) Poor patient survival correlates with a higher expression of the CSVTCG-specific TSP-1 receptor on tumor cells. In this paper we discuss the evidence that TSP-1 promotes tumor progression and present a Accepted

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