𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Expression of hypoxia-inducible factor 1α in brain tumors : Association with angiogenesis, invasion, and progression

✍ Scribed by David Zagzag; Hua Zhong; Joanne M. Scalzitti; Erik Laughner; Jonathan W. Simons; Gregg L. Semenza


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
916 KB
Volume
88
Category
Article
ISSN
0008-543X

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Hypoxia inducible factors 1α and 2α are
✍ A. Giatromanolaki; E. Sivridis; C. Simopoulos; A. Polychronidis; K.C. Gatter; A. 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 235 KB

Aims: To investigate the significance of the hypoxia inducible factors HIF-1a and HIF-2a in gallbladder adenocarcinomas and their relation to angiogenesis and to the expression of VEGF, an angiogenic factor transcriptionally regulated by HIFas. Methods: HIF-1a and 2a expression was assessed immunohi

Expression of hypoxia-inducible factor-1
✍ Toshio Kuwai; Yasuhiko Kitadai; Shinji Tanaka; Seiji Onogawa; Norimasa Matsutani 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 398 KB

## Abstract HIF‐1 is reported to transactivate expression of VEGF, which is an important angiogenic factor. To determine whether HIF‐1α plays a role in angiogenesis through its regulation of VEGF, we examined expression of HIF‐1α and its relation to clinicopathologic features, VEGF expression and p

2-oxoglutarate downregulates expression
✍ Ken Matsumoto; Shigehiko Imagawa; Naoshi Obara; Norio Suzuki; Satoru Takahashi; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 299 KB

## Abstract In oxygenated cells, hypoxia‐inducible factor‐1 (HIF‐1) α subunits are rapidly degraded by a mechanism that involves ubiquitination by the von Hippel–Lindau tumor suppressor E3 ligase complex using 2‐oxoglutarate as a substrate. We examined the effect of 2‐oxoglutarate on the production

Increased levels of hypoxia-inducible fa
✍ Changbao Chen; Hua Zhou; Feng Wei; Liang Jiang; Xiaoguang Liu; Zhongjun Liu; Qin 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 263 KB

## Abstract Hypoxia‐inducible factor (HIF)‐1α is a key nuclear transcription factor that regulates the cellular response to hypoxia, and is important for solid tumor growth and survival. However, the underlying role of HIF‐1α in human chondrosarcoma has not been well characterized. This study aims

Vascular endothelial growth factor expre
✍ Kimitoshi Inoue; Yuichi Ozeki; Toshiyuki Suganuma; Yoshiaki Sugiura; Susumu Tana 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 245 KB 👁 2 views

## Background: Angiogenesis is essential for solid tumor growth and metastasis. vascular endothelial growth factor (vegf), a recently identified growth factor with significant angiogenic properties, may be a major tumor angiogenesis regulator in vivo. conversely, there have been few studies of the

Expression of hypoxia-inducible factor-1
✍ Dirk Vordermark 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 247 KB

better if the lactate dehydrogenase value was withdrawn from the staging system proposal. Clinical staging systems are developed to provide accurate prognostic information for diagnostic therapeutic decision-making and, moreover, to facilitate communication between clinicians. Therefore, clinical s