Thrombospondin (TSP-1) is a large glycoprotein secreted by platelets and synthesized by many cell types, including endothelial and tumor cells. Although controversy exists about the biological function of TSP-1, the following observations suggest that TSP-1 may potentiate tumor progression. (1) Tumo
The role of thrombospondin-1 in apoptosis
β Scribed by P. Friedl; P. Vischer; M. A. Freyberg
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 141 KB
- Volume
- 59
- Category
- Article
- ISSN
- 1420-682X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Thrombospondinβ1 (TSPβ1) treatment of dermal microvascular endothelial cells (MvEC) has been shown to upregulate Fas ligand (FasL) and to induce apoptosis by a mechanism that requires caspaseβ8 activity. We have examined the potential antiβangiogenic effects of TSPβ1 on primary human br
The thrombospondins are a family of proteins found widely in the embryonic extracellular matrix. Like most matrix proteins, thrombospondins are modular and contain a series of repeated domains arrayed between globular amino and carboxyl terminal domains. In recent years, other proteins that share th
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Normal arteries are characterized by a low turnover of endothelial (EC) and smooth muscle cells (SMC). Different mechanisms protect the EC and SMC against apoptosis in the normal artery. In hypertension, SMC replication is increased but this is not counterbalanced by increased apoptosis, resulting i