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Tumor necrosis factor causes amplification of arachidonic acid metabolism in response to interleukin 1, bradykinin, and other agonists

✍ Scribed by Ronald M. Burch; Carol W. Tiffany

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 510 KB
Volume: 141
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041410113

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✦ Synopsis

Tumor necrosis factor stimulated prostaglandin EL synthesis in Swiss 3T3 fibroblasts. lnterleukin 1 also stimulated prostaglandin synthesis. Simultaneous addition of tumor necrosis factor and interleukin 1 synergistically stimulated prostaglandin synthesis, even when both growth factors were added at what would be supramaximal concentrations by themselves. Several smal I peptides and nonpeptides rapidly stimulate prostaglandin synthesis in these cells. Pretreatment with tumor necrosis factor synergistically enhanced prostaglandin synthesis in response to bradykinin, bombesin, thrombin, norepinephrine, and platelet-activating factor. Thus, tumor necrosis factor stimulates prostaglandin synthesis and greatly amplifies prostaglandin synthesis in response to other agonists. This finding may have significance in chronic inflammatory diseases such as rheumatoid arthritis in which several hormones and growth factors niay synergistically augment eicosanoid synthesis.

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